En la fase de grupos de esta participarán los 10 equipos clasificados de la tercera ronda previa (5 de la de campeones de liga y 5 de los no campeones de liga) junto a los siguientes 22 equipos que clasificaron de forma directa, dando un total de 32 equipos para 8 grupos. Se jugarán seis fechas en duelos de ida y vuelta, para luego pasar a las fases de eliminación directa.
| Grupo A | PTS | PJ | PG | PE | PP | GF | GC | DIF |
| 1. |  |
Manchester United | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 2. |  |
Bayer Leverkusen | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 3. |  |
Shakhtar Donetsk | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| 4. |  |
Real Sociedad | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
| Local | Visitante | Fecha - Hora | Sede | En TV |
| Man. United | |
4 - 2 | |
B. Leverkusen | 17/09 - 15:45 hrs. | Manchester (ING) | |
| Real Sociedad | |
0 - 2 | |
Shakhtar D. | 17/09 - 15:45 Hrs. | Sn. Seba. (ESP) | |
| Shakhtar D. | |
1 - 1 | |
Man. United | 02/10 - 15:45 hrs. | Donetsk (UCR) | |
| B. Leverkusen | |
2 - 1 | |
Real Sociedad | 02/10 - 15:45 hrs | Leverkusen (ALE) | |
| B. Leverkusen | |
4 - 0 | |
Shakhtar D. | 23/10 - 15:45 Hrs. | Leverkusen (ALE) | |
| Man. United | |
1 - 0 | |
Real Sociedad | 23/10 - 15:45 Hrs. | Manchester (ING) | |
| Shakhtar D. | |
0- 0 | |
B. Leverkusen | 05/11 - 16:45 Hrs. | Donetsk (UCR) | |
| Real Sociedad | |
0 - 0 | |
Man. United | 05/11 - 16:45 Hrs. | Sn. Seba. (ESP) | |
| B. Leverkusen | |
0 - 5 | |
Man. United | 27/11 - 16:45 Hrs. | Leverkusen (ALE) | |
| Shakhtar D. | |
4 - 0 | |
Real Sociedad | 27/11 - 16:45 Hrs. | Donetsk (UCR) | |
| Man. United | |
1 - 0 | |
Shakhtar D. | 10/12 - 16:45 Hrs. | Manchester (ING) | |
| Real Sociedad | |
0 - 1 | |
B. Leverkusen | 10/12 - 16:45 Hrs. | Sn. Seba. (ESP) |
| Grupo B | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
Real Madrid | 16 | 6 | 5 | 1 | 0 | 20 | 5 | 15 |
| 2. |  |
Galatasaray | 7 | 6 | 2 | 1 | 3 | 8 | 14 | -6 |
| 2. |  |
Juventus | 6 | 6 | 1 | 3 | 2 | 9 | 9 | 0 |
| 4. |  |
Copenhague | 4 | 6 | 1 | 1 | 4 | 4 | 13 | -9 |
| Local | Visitante | Fecha - Hora | Sede | En TV |
| Galatasaray | |
1 - 6 | |
Real Madrid | 17/09 - 15:45 hrs. | Estambul (TUR) | |
| Copenhague | |
1 - 1 | |
Juventus | 17/09 - 15:45 Hrs. | Copenhague (DIN) | |
| Juventus | |
2 - 2 | |
Galatasaray | 02/10 - 15:45 hrs. | Turín (ITA) | |
| Real Madrid | |
4 - 0 | |
Copenhague | 02/10 - 15:45 hrs. | Madrid (ESP) | |
| Real Madrid | |
2 - 1 | |
Juventus | 23/10 - 15:45 Hrs. | Madrid (ESP) | |
| Galatasaray | |
3 - 1 | |
Copenhague | 23/10 - 15:45 Hrs. | Estambul (TUR) | |
| Juventus | |
2 - 2 | |
Real Madrid | 05/11 - 16:45 Hrs. | Turín (ITA) | |
| Copenhague | |
1 - 0 | |
Galatasaray | 05/11 - 16:45 Hrs. | Copenhague (DIN) | |
| Real Madrid | |
4 - 1 | |
Galatasaray | 27/11 - 16:45 Hrs. | Madrid (ESP) | |
| Juventus | |
3 - 1 | |
Copenhague | 27/11 - 16:45 Hrs. | Turín (ITA) | |
| Galatasaray | |
1 - 0 | |
Juventus | 10/12 - 16:45 Hrs. | Estambul (TUR) | |
| Copenhague | |
0 - 2 | |
Real Madrid | 10/12 - 16:45 Hrs. | Copenhague (DIN) |
| Grupo C | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
Paris Saint-Germain | 13 | 6 | 4 | 1 | 1 | 16 | 5 | 11 |
| 2. |  |
Olympiacos FC | 10 | 6 | 3 | 1 | 2 | 10 | 1 | 9 |
| 3. |  |
SL Benfica | 7 | 6 | 3 | 1 | 2 | 8 | 8 | 0 |
| 4. |  |
RSC Anderlecht | 1 | 6 | 0 | 1 | 5 | 4 | 17 | -13 |
| Local | Visitante | Fecha - Hora | Sede | En TV |
| Benfica | |
2 - 0 | |
Anderlecht | 17/09 - 15:45 hrs. | Lisboa (POR) | |
| Olympiacos | |
1 - 4 | |
PSG | 17/09 - 15:45 hrs. | El Pireo (GRE) | |
| PSG | |
3 - 0 | |
Benfica | 02/10 - 15:45 hrs. | Paris (FRA) | |
| Anderlecht | |
0 - 3 | |
Olympiacos | 02/10 - 15:45 hrs. | Bruselas (BEL) | |
| Anderlecht | |
0 - 5 | |
PSG | 23/10 - 15:45 hrs. | Bruselas (BEL) | |
| Benfica | |
1 - 1 | |
Olympiacos | 23/10 - 15:45 hrs. | Lisboa (POR) | |
| PSG | |
1 - 1 | |
Anderlecht | 05/11 - 16:45 hrs. | Paris (FRA) | |
| Olympiacos | |
1 - 0 | |
Benfica | 05/11 - 16:45 hrs. | El Pireo (GRE) | |
| Anderlecht | |
2 - 3 | |
Benfica | 27/11 - 16:45 hrs. | Bruselas (BEL) | |
| PSG | |
2 - 1 | |
Olympiacos | 27/11 - 16:45 hrs. | Paris (FRA) | |
| Benfica | |
2 - 1 | |
PSG | 10/12 - 16:45 hrs. | Lisboa (POR) | |
| Olympiacos | |
3 - 1 | |
Anderlecht | 10/12 - 16:45 hrs. | El Pireo (GRE) |
| Grupo D | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
FC Bayern Múnich | 15 | 6 | 5 | 0 | 1 | 17 | 5 | 12 |
| 2. |  |
Manchester City FC | 15 | 6 | 5 | 0 | 1 | 17 | 10 | 7 |
| 3. |  |
CSKA Moscú | 4 | 6 | 1 | 1 | 4 | 8 | 15 | -7 |
| 4. |  |
Viktoria Plzeň | 1 | 6 | 0 | 1 | 5 | 5 | 17 | -12 |
| Local | Visitante | Fecha - Hora | Sede | En TV |
| Bayern | |
3 - 0 | |
CSKA | 17/09 - 15:45 hrs. | Múnich (ALE) | |
| Plzeň | |
0 - 3 | |
Man. City | 17/09 - 15:45 hrs. | Plzeň (R.CHE) | |
| CSKA | |
3 - 2 | |
Plzeň | 02/10 - 13:00 hrs. | Moscú (RUS) | |
| Man. City | |
1 - 3 | |
Bayern | 02/10 - 15:45 hrs. | Manchester (ING) | |
| CSKA | |
1 - 2 | |
Man. City | 23/10 - 13:00 hrs. | Moscú (RUS) | |
| Bayern | |
5 - 0 | |
Plzeň | 23/10 - 15:45 hrs. | Múnich (ALE) | |
| Man. City | |
4 - 2 | |
CSKA | 05/11 - 16:45 hrs. | Manchester (ING) | |
| Plzeň | |
0 - 1 | |
Bayern | 05/11 - 16:45 hrs. | Plzeň (R.CHE) | |
| CSKA | |
1 - 3 | |
Bayern | 27/11 - 14:00 hrs. | Moscú (RUS) | |
| Man. City | |
4 - 2 | |
Plzeň | 27/11 - 16:45 hrs. | Manchester (ING) | |
| Bayern | |
2 - 3 | |
Man. City | 10/12 - 16:45 Hrs. | Múnich (ALE) | |
| Plzeň | |
1 - 1 | |
CSKA | 10/12 - 16:45 Hrs | Plzeň (R.CHE) |
| Grupo E | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
Chelsea FC | 12 | 6 | 4 | 0 | 2 | 12 | 3 | 9 |
| 2. |  |
FC Schalke 04 | 10 | 6 | 3 | 1 | 2 | 6 | 6 | 0 |
| 3. |  |
FC Basilea | 8 | 6 | 2 | 2 | 2 | 5 | 6 | -1 |
| 4. |  |
Steaua București | 3 | 6 | 0 | 3 | 3 | 2 | 10 | -8 |
| Local | Visitante | Fecha - Hora | Sede | En TV |
| Schalke | |
3 - 0 | |
Steaua | 18/09 - 15:45 hrs. | Gelsen. (ALE) | |
| Chelsea | |
1 - 2 | |
Basel | 18/09 - 15:45 hrs. | Londres (ALE) | |
| Basel | |
0 - 1 | |
Schalke | 01/10 - 15:45 hrs. | Baseilea (SUI) | |
| Steaua | |
0 - 4 | |
Chelsea | 01/10 - 15:45 hrs. | Bucarest (RUM) | |
| Steaua | |
1 - 1 | |
Basel | 22/10 - 15:45 hrs. | ||
| Schalke | |
0 - 3 | |
Chelsea | 22/10 - 15:45 hrs. | ||
| Basel | |
1 - 1 | |
Steaua | 06/11 - 16:45 hrs. | ||
| Chelsea | |
3 - 0 | |
Schalke | 06/11 - 16:45 hrs. | ||
| Steaua | |
0 - 0 | |
Schalke | 26/11 - 16:45 hrs. | ||
| Basel | |
1 - 0 | |
Chelsea | 26/10 - 16:45 hrs. | ||
| Schalke | |
2 - 0 | |
Basel | 11/12 - 16:45 hrs. | ||
| Chelsea | |
1 - 0 | |
Steaua | 11/12 - 16:45 hrs. |
| Grupo F | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
Arsenal FC | 12 | 6 | 4 | 0 | 2 | 8 | 5 | 3 |
| 2. |  |
Borussia Dortmund | 12 | 6 | 4 | 0 | 2 | 11 | 6 | 5 |
| 3. |  |
SSC Napoli | 12 | 6 | 4 | 0 | 2 | 10 | 9 | 1 |
| 4. |  |
Olympique de Marsella | 0 | 6 | 0 | 0 | 6 | 5 | 13 | -8 |
| Local | Visitante | Fecha - Hora | Sede | En TV |
| O. Marsella | |
1 - 2 | |
Arsenal | 18/09 - 15:45 hrs. | Marsella (FRA) | |
| Napoli | |
2 - 1 | |
Dortmund | 18/09 - 15:45 hrs. | Nápoles (ITA) | |
| Dortmund | |
3 - 0 | |
O. Marsella | 01/10 - 15:45 hrs. | Dortmund (ALE) | |
| Arsenal | |
2 - 0 | |
Napoli | 01/10 - 15:45 hrs. | Londres (ALE) | |
| Arsenal | |
1 - 2 | |
Dortmund | 22/10 - 15:45 hrs. | Londres (ALE) | |
| O. Marsella | |
1 - 2 | |
Napoli | 22/10 - 15:45 hrs. | Marsella (FRA) | |
| Dortmund | |
0 - 1 | |
Arsenal | 06/11 - 16:45 hrs. | Dortmund (ALE) | |
| Napoli | |
3 - 2 | |
O. Marsella | 06/11 - 16:45 hrs. | Nápoles (ITA) | |
| Arsenal | |
2 - 0 | |
O. Marsella | 26/11 - 16:45 hrs. | Londres (ALE) | |
| Dortmund | |
3 - 1 | |
Napoli | 26/11 - 16:45 hrs. | Dortmund (ALE) | |
| O. Marsella | |
1 - 2 | |
Dortmund | 11/12 - 16:45 hrs. | Marsella (FRA) | |
| Napoli | |
2 - 0 | |
Arsenal | 11/12 - 16:45 hrs. | Nápoles (ITA) |
| Grupo G | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
Club Atlético de Madrid | 16 | 6 | 5 | 1 | 0 | 15 | 3 | 12 |
| 2. |  |
FC Zenit | 6 | 6 | 1 | 3 | 2 | 4 | 7 | -3 |
| 3. |  |
FC Porto | 5 | 6 | 1 | 2 | 3 | 4 | 7 | -3 |
| 4. |  |
FK Austria Viena | 5 | 6 | 1 | 2 | 3 | 6 | 12 | -6 |
| Local | Visitante | Fecha - Hora | Sede | En TV |
| Austria Viena | |
0 - 1 | |
Porto | 18/09 - 15:45 hrs. | Viena (AUS) | |
| Atlético | |
3 - 1 | |
Zenit | 18/09 - 15:45 hrs. | Madrid (ESP) | |
| Zenit | |
0 - 0 | |
Austria Viena | 01/10 - 13:00 hrs. | San Peters. (RUS) | |
| Porto | |
1 - 2 | |
Atlético | 01/10 - 15:45 hrs. | Oporto (POR) | |
| Porto | |
0 - 1 | |
Zenit | 22/10 - 13:00 hrs. | Oporto (POR) | |
| Austria Viena | |
0 - 3 | |
Atlético | 22/10 - 15:45 hrs. | Viena (AUS) | |
| Zenit | |
1 - 1 | |
Porto | 06/11 - 16:45 hrs. | San Peters. (RUS) | |
| Atlético | |
4 - 0 | |
Austria Viena | 06/11 - 16:45 hrs. | Madrid (ESP) | |
| Zenit | |
1 - 1 | |
Atlético | 26/11 - 14:00 hrs. | San Peters. (RUS) | |
| Porto | |
1 - 1 | |
Austria Viena | 26/11 - 16:45 hrs. | Oporto (POR) | |
| Austria Viena | |
4 - 1 | |
Zenit | 11/12 - 16:45 hrs. | Viena (AUS) | |
| Atlético | |
2 - 0 | |
Porto | 11/12 - 16:45 hrs. | Madrid (ESP) |
| Grupo H | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
FC Barcelona | 13 | 6 | 4 | 1 | 1 | 16 | 5 | 11 |
| 2. |  |
AC Milan | 9 | 6 | 2 | 3 | 1 | 8 | 5 | 3 |
| 3. |  |
AFC Ajax | 8 | 6 | 2 | 2 | 2 | 5 | 8 | -3 |
| 4. |  |
Celtic FC | 3 | 6 | 1 | 0 | 5 | 3 | 14 | -11 |
| Local | Visitante | Fecha - Hora | Sede | En TV |
| Milan | |
2 - 0 | |
Celtic | 18/09 - 15:45 hrs. | Milan (ITA) | |
| Barcelona | |
4 - 0 | |
Ajax | 18/09 - 15:45 hrs. | Barcelona (ESP) | |
| Ajax | |
1 - 1 | |
Milan | 01/10 - 15:45 hrs. | Ámsterdam (HOL) | |
| Celtic | |
0 - 1 | |
Barcelona | 01/10 - 15:45 hrs. | Glasgow (ESC) | |
| Celtic | |
2 - 1 | |
Ajax | 22/10 - 15:45 hrs. | Glasgow (ESC) | |
| Milan | |
1 - 1 | |
Barcelona | 22/10 - 15:45 hrs. | Milan (ITA) | |
| Ajax | |
1 - 0 | |
Celtic | 06/11 - 16:45 hrs. | Ámsterdam (HOL) | |
| Barcelona | |
3 - 1 | |
Milan | 06/11 - 16:45 hrs. | Barcelona (ESP) | |
| Celtic | |
0 - 3 | |
Milan | 26/11 - 16:45 hrs. | Glasgow (ESC) | |
| Ajax | |
2 - 1 | |
Barcelona | 26/11 - 16:45 hrs. | Ámsterdam (HOL) | |
| Milan | |
0 - 0 | |
Ajax | 11/12 - 16:45 hrs. | Milan (ITA) | |
| Barcelona | |
6 - 1 | |
Celtic | 11/12 - 16:45 hrs. | Barcelona (ESP) |
| G | Partidos | Ida | Vuelta |
| 1 | Manchester City | |
vs. | |
Barcelona | 0 - 2 | 1 - 2 |
| 2 | Bayer Leverkusen | |
vs. | |
París Saint Germain | 0 - 4 | 1 - 2 |
| 3 | Milan | |
vs. | |
Atlético de Madrid | 0 - 1 | 1 - 4 |
| 4 | Arsenal | |
vs. | |
Bayern Munich | 0 - 2 | 1 - 1 |
| 5 | Olympiacos | |
vs. | |
Manchester United | 2 - 0 | 0 - 3 |
| 6 | Zenit | |
vs. | |
Borussia Dortmund | 2 - 4 | 2 - 1 |
| 7 | Galatasaray | |
vs. | |
Chelsea | 1 - 1 | 0 - 2 |
| 8 | Schalke 04 | |
vs. | |
Real Madrid | 1 - 6 | 1 - 3 |
| G | Partidos | Ida | Vuelta |
| - | Barcelona | |
vs. | |
Atlético de Madrid | 1 - 1 | 0 -1 |
| - | Manchester United | |
vs. | |
Bayern Munich | 1 - 1 | 1 - 3 |
| - | Paris Saint Germain | |
vs. | |
Chelsea | 3 - 1 | 0 - 2 |
| - | Real Madrid | |
vs. | |
Borussia Dortmund | 3 - 0 | 0 - 2 |
| G | Partidos | Ida | Vuelta |
| - | Atlético de Madrid | |
vs. | |
Chelsea | 1 - 1 | 3 - 1 |
| - | Real Madrid | |
vs. | |
Bayern Munich | 1 - 0 | 4 - 0 |
| G | Rivales | Final | |
| - | Real Madrid | |
vs. | |
Atlético de Madrid | - | |
