La Fase grupal del torneo está compuesta por ocho grupos de cuatro equipos cada uno. A los octavos de final clasifican los dos mejores rendimientos de cada zona. En la fase de los 16 mejores las parejas se arman de acuerdo a la ubicación de cada uno entre todos los clasificados. El mejor clasificado, juega con el peor y así sucesivamente. Lo mismo ocurre en las siguientes rondas.
| G | Partidos | Ida | Vuelta |
| G9 | Emelec |  |
vs. |  |
Tigres | 1-0 | 0-2 |
| G10 | I. Santa Fe |  |
vs. |  |
Inter Porto Alegre | 1-0 | 0-2 |
| G11 | Guaraní |  |
vs. |  |
Racing | 1-0 | 0-0 |
| G12 | River Plate |  |
vs. |  |
Cruzeiro | 0-1 | 3-0 |
| G | Partidos | Ida | Vuelta |
| A | Boca Juniors |  |
vs. | |
River Plate | 0-1 | 0-0* |
| B | Tigres * | |
vs. |  |
Universitario (BOL) | 2-1 | 1-1 |
| C | Internacional* | |
vs. |  |
Atlético Mineiro | 2-2 | 3-1 |
| D | Corinthians |  |
vs. | |
Guaraní* | 0-2 | 0-1 |
| E | Racing Club | |
vs. |  |
Montevideo Wanderers | 1-1 | 2-1 |
| F | Santa Fe* | |
vs. |  |
Estudiantes | 1-2 | 2-0 |
| G | Atlético Nacional |  |
vs. | |
Emelec | 0-2 | 1-0 |
| H | Cruzeiro* | |
vs. |  |
Sao Paulo | 0-1 | 1-0(4-3) |
| G | Partidos | Ida | Vuelta |
| G1 | Alianza de Lima |  |
vs. |  |
Huracan* | 0 - 4 | 0 - 0 |
| G4 | Morelia |  |
vs. |  |
The Strongest* | 1 - 1 | 0 - 2 |
| G6 | Corinthians* | |
vs. |  |
Once Caldas | 4 - 0 | 1 - 1 |
| G3 | Dep. Tachira* |  |
vs. |  |
Cerro Porteño | 2 - 1 | 2 - 2 |
| G2 | Indep. del Valle |  |
vs. | |
Estudiantes |
1 - 0 | 0 - 4 |
| G5 | Palestino |  |
vs. |  |
Nacional (URU) | 1 - 0 | 1 - 2 |
| Grupo 1 | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. | |
Indep. Santa Fe | 12 | 6 | 4 | 0 | 2 | 10 | 5 | 5 |
| 2. | |
Atético Mineiro | 9 | 6 | 3 | 0 | 3 | 5 | 4 | 1 |
| 3. |  |
Colo Colo | 9 | 6 | 3 | 0 | 3 | 8 | 9 | -1 |
| 4. |  |
Atlas | 6 | 6 | 2 | 0 | 4 | 4 | 9 | -5 |
| Local | Visitante | Fecha - Hora | Ciudad |
| Atlas | |
0 - 1 | |
Indep. Santa Fe | 17/02 - 23:45 h | Guadalajara |
| Colo-Colo | |
2 - 0 | |
Atlético Mineiro | 18/02 - 21:00 h | Santiago |
| Atlético Mineiro | |
0 - 1 | |
Atlas | 25/02 - 19:45 h | Belo Horizonte |
| Indep. Santa Fe | |
3 - 1 | |
Colo-Colo | 26/02 - 22:30 h | Bogotá |
| Colo-Colo | |
2 - 0 | |
Atlas | 04/03 - 19:45 h | Santiago |
| Indep. Santa Fe | |
0 - 1 | |
Atlético Mineiro | 18/03 - 22:00 h | Bogotá |
| Atlas | |
1 - 3 | |
Colo-Colo | 07/04 - 22:15 h | Guadalajara |
| Atlético Mineiro | |
2 - 0 | |
Indep. Santa Fe | 09/04 - 21:45 h | Belo Horizonte |
| Atlas | |
1 - 0 | |
Atlético Mineiro | 15/04 - 22:00 h | Guadalajara |
| Colo-Colo | |
0 - 3 | |
Indep. Santa Fe | 15/04 - 22:00 h | Santiago |
| Atlético Mineiro | |
2 - 0 | |
Colo-Colo | 22/04 - 19:45 h | Belo Horizonte |
| Indep. Santa Fe | |
2 - 1 | |
Atlas | 22/04 - 19:45 h | Bogotá |
| Grupo 2 | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
Corinthians | 13 | 6 | 4 | 1 | 1 | 9 | 3 | 6 |
| 2. |  |
Sao Paulo | 12 | 6 | 4 | 0 | 2 | 9 | 4 | 5 |
| 3. |  |
San Lorenzo | 7 | 6 | 2 | 1 | 3 | 3 | 4 | -1 |
| 4. |  |
Danubio | 3 | 6 | 1 | 0 | 5 | 4 | 14 | -10 |
| Local | Visitante | Fecha - Hora | Ciudad |
| Corinthians | |
2 - 0 | |
São Paulo | 18/02 - 21:00 h | São Paulo |
| Danubio | |
1 - 2 | |
San Lorenzo | 19/02 - 19:45 h | Montevideo |
| São Paulo | |
4 - 0 | |
Danubio | 25/02 - 22:00 h | São Paulo |
| San Lorenzo | |
0 - 1 | |
Corinthians | 04/03 - 22:00 h | Buenos Aires |
| Danubio | |
1 - 2 | |
Corinthians | 17/03 - 19:30 h | Montevideo |
| São Paulo | |
1 - 0 | |
San Lorenzo | 18/03 - 22:00 h | São Paulo |
| San Lorenzo | |
1 - 0 | |
São Paulo | 01/04 - 22:00 h | Buenos Aires |
| Corinthians | |
4 - 0 | |
Danubio | 01/04 - 22:00 h | São Paulo |
| Danubio | |
1 - 2 | |
São Paulo | 15/04 - 22:00 h | Montevideo |
| Corinthians | |
0 - 0 | |
San Lorenzo | 16/04 - 22:00 h | São Paulo |
| San Lorenzo | |
0 - 1 | |
Danubio | 22/04 - 22:00 h | Buenos Aires |
| São Paulo | |
2 - 0 | |
Corinthians | 22/04 - 22:00 h | São Paulo |
| Grupo 3 | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. | |
Cruzeiro | 11 | 6 | 3 | 2 | 1 | 8 | 3 | 5 |
| 2. | |
Universitario de Sucre | 9 | 6 | 2 | 3 | 1 | 4 | 3 | 1 |
| 3. | |
Huracán | 7 | 6 | 1 | 4 | 1 | 6 | 7 | -1 |
| 4. |  |
Mineros de Guayana | 4 | 6 | 1 | 1 | 4 | 5 | 10 | -5 |
| Local | Visitante | Fecha - Hora | Ciudad |
| Huracán | |
2 - 2 | |
Mineros | 24/02 - 19:00 h | Bs. Aires |
| Universitario de Sucre | |
0 - 0 | |
Cruzeiro | 25/02 - 22:00 h | Sucre |
| Mineros | |
0 - 1 | |
Universitario de Sucre | 03/03 - 19:45 h | Guayana |
| Cruzeiro | |
0 - 0 | |
Huracán | 03/03 - 22:00 h | Belo Horizonte |
| Universitario de Sucre | |
0 - 0 | |
Huracán | 10/03 - 19:30 h | Sucre |
| Mineros | |
0 - 2 | |
Cruzeiro | 19/03 - 21:45 h | Guayana |
| Huracán | |
1 - 1 | |
Universitario de Sucre | 08/04 - 19:45 h | Bs. Aires |
| Cruzeiro | |
3 - 0 | |
Mineros | 08/04 - 22:00 h | Belo Horizonte |
| Huracán | |
3 - 1 | |
Cruzeiro | 14/04 - 19:00 h | Bs. Aires |
| Universitario de Sucre | |
2 - 0 | |
Mineros | 14/04 - 18:30 h | Sucre |
| Cruzeiro | |
2 - 0 | |
Universitario de Sucre | 21/04 - 20:30 h | Belo Horizonte |
| Mineros | |
0 - 2 | |
Huracán | 21/04 - 20:30 h | Guayana |
| Grupo 4 | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. | |
Internacional | 13 | 6 | 4 | 1 | 1 | 13 | 7 | 6 |
| 2. | |
Emelec | 10 | 6 | 3 | 1 | 2 | 9 | 5 | 4 |
| 3. | |
The Strongest | 9 | 6 | 3 | 0 | 3 | 10 | 11 | -1 |
| 4. |  |
Universidad de Chile | 3 | 6 | 1 | 0 | 5 | 7 | 16 | -9 |
| Local | Visitante | Fecha - Hora | Ciudad |
| Universidad de Chile | |
0 - 1 | |
Emelec | 17/02 - 19:15 h | Santiago |
| The Strongest | |
3 - 1 | |
Internacional | 17/02 - 21:30 h | La Paz |
| Emelec | |
3 - 0 | |
The Strongest | 24/02 - 23:30 h | Guayaquil |
| Internacional | |
3 - 1 | |
Universidad de Chile | 26/02 - 20:15 h | Porto Alegre |
| Internacional | |
3 - 2 | |
Emelec | 04/03 - 22:00 h | Porto Alegre |
| Universidad de Chile | |
3 - 1 | |
The Strongest | 05/03 - 21:30 h | Santiago |
| Emelec | |
1 - 1 | |
Internacional | 18/03 - 19:45 h | Guayaquil |
| The Strongest | |
5 - 3 | |
Universidad de Chile | 17/03 - 22:15 h | La Paz |
| The Strongest | |
1 - 0 | |
Emelec | 14/04 - 23:30 h | La Paz |
| Universidad de Chile | |
0 - 4 | |
Internacional | 16/04 - 22:00 h | Santiago |
| Emelec | |
2 - 0 | |
Universidad de Chile | 22/04 - 17:30 h | Guayaquil |
| Internacional | |
1 - 0 | |
The Strongest | 22/04 - 17:30 h | Porto Alegre |
| Grupo 5 | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. |  |
Boca Juniors | 18 | 6 | 6 | 0 | 0 | 19 | 2 | 17 |
| 2. | |
Montevideo Wanderers | 10 | 6 | 3 | 1 | 2 | 9 | 8 | 1 |
| 3. | |
Palestino | 7 | 6 | 2 | 1 | 3 | 6 | 6 | 0 |
| 4. |  |
Zamora | 0 | 6 | 0 | 0 | 6 | 3 | 21 | -18 |
| Local | Visitante | Fecha - Hora | Ciudad |
| Montevideo Wanderers | |
3 - 2 | |
Deportivo Zamora | 17/02 - 19:15 h | Montevideo |
| Palestino | |
0 - 2 | |
Boca Juniors | 18/02 - 18:45 h | Santiago |
| Boca Juniors | |
2 - 1 | |
Montevideo Wanderers | 26/02 - 20:15 h | Bs. Aires |
| Deportivo Zamora | |
0 - 1 | |
Palestino | 26/02 - 22:30 h | Barinas |
| Montevideo Wanderers | |
1 - 0 | |
Palestino | 10/03 - 19:30 h | Montevideo |
| Boca Juniors | |
5 - 0 | |
Deportivo Zamora | 11/03 - 20:00 h | Bs. Aires |
| Deportivo Zamora | |
1 - 5 | |
Boca Juniors | 17/03 - 22:15 h | Barinas |
| Palestino | |
1 - 1 | |
Montevideo Wanderers | 19/03 - 20:00 h | Santiago |
| Palestino | |
4 - 0 | |
Deportivo Zamora | 07/04 - 20:00 h | Santiago |
| Montevideo Wanderers | |
0 - 3 | |
Boca Juniors | 09/04 - 21:45 h | Montevideo |
| Deportivo Zamora | |
0 - 3 | |
Montevideo Wanderers | 16/04 - 19:45 h | Barinas |
| Boca Juniors | |
2 - 0 | |
Palestino | 16/04 - 19:45 h | Bs. Aires |
| Grupo 6 | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. | |
Tigres | 14 | 6 | 4 | 2 | 0 | 16 | 7 | 9 |
| 2. | |
River Plate | 7 | 6 | 1 | 4 | 1 | 8 | 7 | 1 |
| 3. |  |
Juan Aurich | 6 | 6 | 1 | 3 | 2 | 9 | 11 | -2 |
| 4. |  |
San José | 4 | 6 | 1 | 2 | 4 | 3 | 11 | -8 |
| Local | Visitante | Fecha - Hora | Ciudad |
| Tigres | |
3 - 0 | |
Juan Aurich | 18/02 - 23:15 h | Nuevo León |
| San José Oruro | |
2 - 0 | |
River Plate | 19/02 - 22:00 h | Oruro |
| River Plate | |
1 - 1 | |
Tigres | 05/03 - 19:15 h | Buenos Aires |
| Juan Aurich | |
2 - 0 | |
San José Oruro | 05/03 - 23:45 h | Chiclayo |
| San José Oruro | |
0 - 1 | |
Tigres | 11/03 - 22:00 h | Oruro |
| Juan Aurich | |
1 - 1 | |
River Plate | 12/03 - 22:15 h | Chiclayo |
| Tigres | |
4 - 0 | |
San José Oruro | 18/03 - 00:00 h | Nuevo León |
| River Plate | |
1 - 1 | |
Juan Aurich | 19/03 - 20:00 h | Buenos Aires |
| San José Oruro | |
1 - 1 | |
Juan Aurich | 07/04 - 22:15 h | Oruro |
| Tigres | |
2 - 2 | |
River Plate | 02/04 - 22:00 h | Nuevo León |
| River Plate | |
3 - 0 | |
San José Oruro | 15/04 - 19:45 h | Buenos Aires |
| Juan Aurich | |
4 - 5 | |
Tigres | 15/04 - 19:45 h | Chiclayo |
| Grupo 7 | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. | |
Atlético Nacional | 11 | 6 | 3 | 2 | 1 | 12 | 7 | 5 |
| 2. |  |
Libertad | 8 | 6 | 2 | 2 | 2 | 5 | 8 | -3 |
| 3. | |
Estudiantes | 10 | 6 | 3 | 1 | 2 | 7 | 3 | 4 |
| 4. |  |
Barcelona | 4 | 6 | 1 | 1 | 4 | 5 | 11 | -6 |
| Local | Visitante | Fecha - Hora | Ciudad |
| Libertad | |
2 - 2 | |
Atlético Nacional | 19/02 - 19:45 h | Asunción |
| Estudiantes | |
3 - 0 | |
Barcelona | 25/02 - 19:45 h | - |
| Barcelona | |
0 - 1 | |
Libertad | 03/03 - 19:45 h | Guayaquil |
| Atlético Nacional | |
1 - 1 | |
Estudiantes | 05/03 - 21:30 h | Medellín |
| Barcelona | |
1 - 2 | |
Atlético Nacional | 11/03 - 22:00 h | Guayaquil |
| Libertad | |
1 - 0 | |
Estudiantes | 12/03 - 19:45 h | Asunción |
| Estudiantes | |
1 - 0 | |
Libertad | 18/03 - 19:45 h | - |
| Atlético Nacional | |
2 - 3 | |
Barcelona | 19/03 - 22:15 h | Medellín |
| Libertad | |
1 - 1 | |
Barcelona | 09/04 - 19:30 h | Asunción |
| Estudiantes | |
0 - 1 | |
Atlético Nacional | 09/04 - 19:30 h | - |
| Atlético Nacional | |
4 - 0 | |
Libertad | 21/04 - 22:45 h | Medellín |
| Barcelona | |
0 - 2 | |
Estudiantes | 21/04 - 22:45 h | Guayaquil |
| Grupo 8 | PTS | PJ | PG | PE | PP | GF | GC | +/- |
| 1. | |
Racing Club | 12 | 6 | 4 | 0 | 2 | 15 | 7 | 8 |
| 2. | |
Guaraní | 9 | 6 | 2 | 3 | 1 | 12 | 10 | 2 |
| 3. |  |
Sporting Cristal | 7 | 6 | 1 | 4 | 1 | 6 | 7 | -1 |
| 4. | |
D. Táchira | 3 | 6 | 0 | 3 | 3 | 6 | 15 | -9 |
| Local | Visitante | Fecha | Ciudad |
| D. Táchira | |
0 - 5 | |
Racing | 17/02 - 21:30 h | San Cristóbal |
| Guaraní | |
2 - 2 | |
Sporting Cristal | 18/02 - 18:45 h | Asunción |
| Racing | |
4 - 1 | |
Guaraní | 24/02 - 21:15 h | Buenos Aires |
| Sporting Cristal | |
1 - 1 | |
D. Táchira | 24/02 - 23:30 h | Lima |
| Guaraní | |
5 - 2 | |
D. Táchira | 10/03 - 21:45 h | Asunción |
| Racing | |
1 - 2 | |
Sporting Cristal | 10/03 - 21:45 h | Buenos Aires |
| D. Táchira | |
1 - 1 | |
Guaraní | 17/03 - 18:00 h | San Cristóbal |
| Sporting Cristal | |
0 - 2 | |
Racing | 17/03 - 19:45 h | Lima |
| Guaranií | |
2 - 0 | |
Racing | 07/04 - 20:00 h | Asunción |
| D. Táchira | |
0 - 0 | |
Sporting Cristal | 08/04 - 19:45 h | San Cristóbal |
| Sporting Cristal | |
1 - 1 | |
Guaraní | 14/04 - 21:15 h | Lima |
| Racing | |
3 - 2 | |
D. Táchira | 14/04 - 21:15 h | Buenos Aires |
| G | Partidos | Ida | Vuelta |
| G14 | - |  |
vs. | |
- | - | - |
| G14 | - | |
vs. | |
- | - | - |
